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Profile
| Academic position | Full Professor |
|---|---|
| Research fields | Parasitology and Biology of Tropical Disease Pathogens,Biochemistry |
| Keywords | drug discovery, binding affinities, 3D structures, Microbial metalo-aminopeptidase inhibitors, in vitro anti-tuberculosis activity |
| Honours and awards | 2025: Annual National Prize of the Cuban Academy of Sciences for outstanding scientific breakthroughs in drug discovery in leishmaniasis 2024: Annual National Prize of the Cuban Academy of Sciences for outstanding scientific breakthroughs in drug discovery in Chagas disease 2019: Annual National Prize of the Cuban Academy of Sciences for outstanding scientific breakthroughs in drug discovery against bacteria and in malaria 2012: Annual National Prize of the Cuban Academy of Sciences for outstanding scientific breakthroughs in protein immobilization (collaborator) |
Current contact address
| Country | Germany |
|---|---|
| City | Hamburg |
| Institution | University of Hamburg / DESY |
| Institute | Institute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation |
Host during sponsorship
| Prof. Dr. Dr. Christian Betzel | Institut für Biochemie und Molekularbiologie, Universität Hamburg (UHH), Hamburg |
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| Start of initial sponsorship | 01/05/2024 |
Programme(s)
| 2023 | Georg Forster Research Fellowship Programme for Experienced Researchers |
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Publications (partial selection)
| 2026 | Mirta Elisa Aguado | Gerardo M. Ojeda‐Carralero | Mario Antonio Rodríguez | Isabella Rúa | Heisy Guerra | Edoardo Bailo Hernández | Guglielmo Coppola | Susana Alberti | Ariatne Rodríguez | Maikel Izquierdo | Christian Betzel | Filippo Pettazzi | Julieta Coro‐Bermello | Erik V. Van der Eycken | Bernhard Westermann | Jorge González‐Bacerio | Daniel G. Rivera: Synthesis and Evaluation of Peptoid‐Based Compound Libraries as Inhibitors of Parasite Metallo‐Aminopeptidases. In: ChemMedChem, 21, 2026, 1-12 |
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| 2024 | Aguado ME, Carvalho S, Valdés-Tresanco ME, Lin D, Padilla-Mejía N, Corpas-López V, Tesařová M, Lukeš J, Gray D, González-Bacerio J, Wyllie S, Field MC: Identification and validation of compounds targeting Leishmania major leucyl-aminopeptidase M17. In: ACS Infect. Dis., 10, 2024, 2002-2017 |
| 2024 | Izquierdo M, Lin D, O’Neill S, Webster LA, Paterson C, Thomas J, Aguado ME, Colina Araújo E, Alpízar-Pedraza D, Joji H, MacLean L, Hope A, Gray DW, Zoltner M, Field MC, González-Bacerio J, De Rycker M: Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity. In: PLoS Negl. Trop. Dis., 18, 2024, e0011956 |
| 2021 | Aguado ME, González-Matos M, Izquierdo M, Quintana J, Field MC, González-Bacerio J: Expression in Escherichia coli, purification and kinetic characterization of LAPLm, a Leishmania major M17-aminopeptidase. In: Protein Expr. Purif., 183, 2021, 105877 |
| 2021 | González-Bacerio J, Arocha I, Aguado ME, Méndez Y, Marsiccobetre S, Izquierdo M, Rivera DG, Figarella K, Uzcategui NL: KBE009: A bestatin-like inhibitor of the Trypanosoma cruzi acidic M17 aminopeptidase with in vitro anti-trypanosomal activity. In: Life, 11, 2021, 1037 |
| 2020 | Izquierdo M, Lin D, O’Neill S, Zoltner M, Webster L, Hope A, Gray DW, Field MC, González-Bacerio J Development of a high-throughput screening assay to identify inhibitors of the major M17-leucyl aminopeptidase from Trypanosoma cruzi using RapidFire mass spectrometry. In: SLAS Discov., doi: 10.1177/2472555220923367, 2020, |
| 2019 | Méndez Y, De Armas G, Pérez I, Rojas T, Valdés-Tresanco ME, Izquierdo M, Alonso del Rivero M, Álvarez-Ginarte YM, Valiente PA, Soto C, de León L, Vasco AV, Scotte WL, Westermann B, González-Bacerio J, Rivera DG: Discovery of potent and selective inhibitors of the Escherichia coli M1-aminopeptidase via multicomponent solid-phase synthesis of tetrazole-peptidomimetics. In: Eur. J. Med. Chem., 163, 2019, 481-499 |
| 2019 | Izquierdo M, Aguado ME, Zoltner M, González-Bacerio J: High-level expression in Escherichia coli, purification and kinetic characterization of LAPTc, a Trypanosoma cruzi M17-aminopeptidase. In: Protein J., 38, 2019, 167-180 |
| 2017 | González-Bacerio J, Maluf SEC, Méndez Y, Pascual I, Florent I, Melo PMS, Budu A, Ferreira JC, Moreno E, Carmona AK, Rivera DG, Alonso del Rivero M, Gazarini ML: KBE009: An antimalarial bestatin-like inhibitor of the Plasmodium falciparum M1 aminopeptidase discovered in an Ugi multicomponent reaction-derived peptidomimetic library. In: Bioorg. Med. Chem., 25, 2017, 4628-4636 |
| 2014 | Méndez Y, Pérez-Labrada K, González-Bacerio J, Valdés G, Chávez MÁ, Osuna J, Charli J-L, Pascual I, Rivera DG: Combinatorial multicomponent access to natural-products-inspired peptidomimetics: Discovery of selective inhibitors of microbial metallo-aminopeptidases. In: ChemMedChem, 9, 2014, 2351-2359 |
| 2014 | González-Bacerio J, Osuna J, Ponce A, Fando R, Figarella K, Méndez Y, Charli J-L, Chávez MÁ: High-level expression in Escherichia coli, purification and kinetic characterization of Plasmodium falciparum M1-aminopeptidase. In: Protein Expr. Purif., 104, 2014, 103-114 |